Ninety-six percent of obese children screened positive for one MS component anomaly, and 74.1 % of obese children had 2 or more abnormal components. Chinese national nutrition and health survey showed that in the year 2002, the prevalence of MS was 35.2 % in obese children. Metabolic Syndrome (MS) is not rare in children and adolescents. The prevalence of obesity has increased dramatically in children and adolescents as China is gradually taking its place as one of the world’s economic giants, it is becoming an important public health problem. TG/HDL-C ratio has a discriminatory power in detecting potential MS in the Chinese obese pediatric population. TG/HDL-C ratio proved a better index than HOMA-IR in screening for MS in obese children and adolescents. Furthermore, the TG/HDL-C ratio was superior to the HOMA-IR indexes even after the control of possible confusions from the gender, age group and puberty stage. TG/HDL-C ratio was a better indicator than the HOMA-IR to screen for a positive diagnosis for MS. The results kept robust after stratified by gender, age group and pubertal stage. TG/HDL-C ratio achieved a larger ROC Area under Curve (AUC = 0.843) than HOMA-IR indexes (0.640, 0.625 for HOMA1-IR, HOMA2-IR respectively) to screen for Metabolic Syndrome. The validity and accuracy between TG/HDL-C ratio and HOMA-IR were compared by Receiver Operating Characteristics analysis (ROC). MethodĪ total sample of 976 children (female286 male690, BMI > =95percentile) aged from 6–16 years underwent a medical assessment including a physical examination and investigations of total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, insulin, glucose, and oral glucose tolerance test to identify the components of Metabolic Syndrome. This study aims to investigate the optimal cut-off values, compare the accuracy for the (TriGlycerides (TG) to High-Density Lipoprotein Cholesterol (HDL-C)) (TG/HDL-C) ratio and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) indexs to identify Metabolic Syndrome in obese pediatric population in China. Based on the MS-CHN2012 definition for Chinese children and adolescents the need to explore and establish a convienent MS screening become imminent. Metabolic Syndrome (MS) is prevalant in China, especially according to the pediatric obesity group.
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